Target and Its Patented Drug(s)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T24823 | Target Info | |||
| Target Name | Lysine-specific histone demethylase 1B (KDM1B) | ||||
| Synonyms | Lysine-specific histone demethylase 2; LSD2; Flavin-containing amine oxidase domain-containing protein 1; C6orf193; AOF1 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | KDM1B | ||||
| Biochemical Class | CH-NH(2) donor oxidoreductase | ||||
| UniProt ID | |||||
| Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
|---|---|---|---|---|---|
| World Intellectual Property Organization (WIPO) | |||||
| Patent ID | WO2013033688 | ||||
| Title | Treatment of Cancer. | ||||
| Abstract | This disclosure provides agents, compositions and methods of treating cancer by inhibiting histone lysine specific demethylase 1 ( LSD1) and/or and a histone lysine specific demethylase 2 (LSD2). Agents and compositions comprise statins and/or inhibitors of LSD1/2. | ||||
| Applicant(s) | The Brigham and Women'S Hospital, Inc | ||||
| Representative Drug(s) | D09OMM | Drug Info | N.A. | Click to Show More | [1] |
| 2 | D0WO5W | Drug Info | N.A. | [1] | |
| 3 | D0Z7HE | Drug Info | N.A. | [1] | |
| Patent ID | WO2011131576 | ||||
| Title | Tranylcypromine Derivatives As Inhibitors of Histone Demethylase Lsd1 and/or Lsd2. | ||||
| Abstract | Tranylcypromine derivatives useful as therapeutic agents, particularly for the prevention and/or treatment of diseases and conditions associated with the activity of histone demethylases LSD1 and LSD2, such as the diseases characterized by deregulation of gene transcription, cell differentiation and proliferation, e.g. tumors, viral infections, are herein described. These compounds belong to the structural formula (I) wherein A and R3 are as defined in the specification. The invention also relates to the preparation of these compounds, as well as to compositions containing them and to therapeutic use thereof. | ||||
| Applicant(s) | Univ Roma | ||||
| Representative Drug(s) | D04OHC | Drug Info | N.A. | Click to Show More | [1] |
| 2 | D0O7IH | Drug Info | N.A. | [1] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | LSD1 inhibitors: a patent review (2010-2015).Expert Opin Ther Pat. 2016 May;26(5):565-80. | ||||
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