Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T17036 Target Info
Target Name Lysine-specific demethylase 4E (KDM4E)
Synonyms Lysine-specific demethylase 4D-like; KDM4DL; KDM4D-like protein
Target Type Patented-recorded Target
Gene Name KDM4E
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
KDM4E_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2010043866
Title Histone Lysine Demethylase Inhibitors.
Abstract The invention provides a compound which is an iV-oxalylglycine derivative of formula (I): a hydroxamic acid derivative of formula (II): or a heteroaryl derivative of fomula (III): wherein n; Z1; Z2; Y1; Y2; A; p; X1; X2; m; R4; B; R5; R6; R7; R8; R9; X3; R10; R11 and R12 are as defined herein, or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of the human 2-oxoglutarate-dependant JMJD2 subfamily of histone demethylases, in particular JMJD2E. Such inhibitors are useful in changing the epigenetic state of cells resulting in the inhibition / activation of chromatin remodelling, multiple gene activation / deactivation, and in treating cancer and other conditions characterised by undesirable cellular proliferation, and psychiatric disorders including depression.
Applicant(s) Isis Innovation Limited
Representative Drug(s) D0O9WS Drug Info IC50 = 300 nM Click to Show More [1]
2 D06ZPF Drug Info IC50 = 600 nM [1]
3 D0D0WU Drug Info IC50 = 1100 nM [1]
4 D03EOJ Drug Info IC50 = 5400 nM [1]
5 D0OR0K Drug Info IC50 = 7900 nM [1]
6 D0WC4Z Drug Info IC50 = 8600 nM [1]
7 D0P7ZY Drug Info IC50 = 11700 nM [1]
8 D0C8CI Drug Info IC50 = 14700 nM [1]
9 D0L7HC Drug Info IC50 = 14700 nM [1]
10 D0YF2M Drug Info IC50 = 14800 nM [1]
11 D0LU7U Drug Info IC50 = 16600 nM [1]
12 D06MHK Drug Info IC50 = 20100 nM [1]
13 D0P5MY Drug Info IC50 = 37100 nM [1]
United States Patent and Trademark Office (USPTO)
Patent ID US20130123344
Title of Health and Human Services. Method of Preventing or Treating Viral Infection with Compounds That Inhibit Jmjd2 Proteins.
Representative Drug(s) D00VLQ Drug Info IC50 = 840 to 12000 nM Click to Show More [1]
2 D03TPE Drug Info IC50 = 840 to 12000 nM [1]
3 D08KYP Drug Info IC50 = 840 to 12000 nM [1]
4 D0P8YL Drug Info IC50 = 840 to 12000 nM [1]
5 D0VS3A Drug Info IC50 = 840 to 12000 nM [1]
Patent ID US20130137720
Title Histone Demethylase Inhibitors and Methods for Using The Same.
Representative Drug(s) D09NCT Drug Info IC50 = 5900 nM [1]
References  Top
REF 1 KDM4 histone demethylase inhibitors for anti-cancer agents: a patent review.Expert Opin Ther Pat. 2015 Feb;25(2):135-44.

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