Target and Its Patented Drug(s)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T09022 | Target Info | |||
| Target Name | Proteasome beta-10 (PS beta-10) | ||||
| Synonyms | Proteasome subunit beta-2i; Proteasome subunit beta type-10; Proteasome MECl-1; Multicatalytic endopeptidase complex subunit MECl-1; Macropain subunit MECl-1; MECL1; Low molecular mass protein 10; LMP10 | ||||
| Target Type | Patented-recorded Target | ||||
| Gene Name | PSMB10 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
|---|---|---|---|---|---|
| World Intellectual Property Organization (WIPO) | |||||
| Patent ID | WO2017156471 | ||||
| Title | Immunoproteasome Inhibitor Analogs. | ||||
| Abstract | The disclosure provides for compounds having immunoproteasome inhibitory activity, and pharmaceutical compositions made thereof. The disclosure further provides for the use of the compounds and compositions in treating various diseases and disorders in a subject that are associated with immunoproteasome activity, including inflammatory disorders, autoimmune disorders, hematological disorders, and neurodegenerative disorders. | ||||
| Applicant(s) | The Regents of the University of California | ||||
| Representative Drug(s) | D01GON | Drug Info | Ki = 740 nM | Click to Show More | [1] |
| 2 | D00GGB | Drug Info | Ki = 750 nM | [1] | |
| 3 | D0DY3A | Drug Info | Ki = 1390 nM | [1] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A patent review of immunoproteasome inhibitors.Expert Opin Ther Pat. 2018 Jul;28(7):517-540. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.