Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T04512 Target Info
Target Name EZH2 Y641F mutant (EZH2 Y641F)
Synonyms Lysine Nmethyltransferase 6 Y641F mutant; Lysine N-methyltransferase 6 Y641F mutant; KMT6 Y641F mutant; Histonelysine Nmethyltransferase EZH2 Y641F mutant; Histone-lysine N-methyltransferase EZH2 Y641F mutant; EZH2 Y641F mutations; ENX1 Y641F mutant; ENX-1 Y641F mutant
Target Type Patented-recorded Target
Gene Name EZH2
UniProt ID
EZH2_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2015010078
Title Substituted 6,5-Fused Bicyclic Heteroaryl Compounds.
Abstract The present invention relates to substituted bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Applicant(s) Epizyme, Inc
Representative Drug(s) D0TA4N Drug Info IC50 = 233 nM Click to Show More [1]
2 D0GT7A Drug Info IC50 = 1990 nM [1]
United States Patent and Trademark Office (USPTO)
Patent ID US20140107122
Title Preparation of Substituted Benzene Compounds As Anticancer Agents.
Representative Drug(s) D0MZ9P Drug Info IC50 < 5 nM Click to Show More [1]
2 D0H8VN Drug Info IC50 = 8.4 nM [1]
3 D0MH5C Drug Info IC50 = 15 nM [1]
References  Top
REF 1 EZH2 inhibitors: a patent review (2014-2016).Expert Opin Ther Pat. 2017 Jul;27(7):797-813.

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