Target and Its Patented Drug(s)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02719 | Target Info | |||
| Target Name | Metabotropic glutamate receptor 3 (mGluR3) | ||||
| Synonyms | mGLUR3; Group III metabotropic glutamate receptor; GPRC1C | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | GRM3 | ||||
| Biochemical Class | GPCR glutamate | ||||
| UniProt ID | |||||
| Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
|---|---|---|---|---|---|
| World Intellectual Property Organization (WIPO) | |||||
| Patent ID | WO2012068067 | ||||
| Title | 4-Substituted-3-Phenylsulfanylmethyl-Bicyclo[3.1.0]Hexane Compounds As Mglur 2/3 Antagonists. | ||||
| Abstract | A mGlu2/3 receptor antagonist of the formula (I):, its uses, and methods for its preparation are described. | ||||
| Applicant(s) | Eli Lilly and Company | ||||
| Representative Drug(s) | D0KV7D | Drug Info | IC50 = 6.2 nM | Click to Show More | [1] |
| 2 | D0SF1E | Drug Info | IC50 = 13.4 nM | [1] | |
| Patent ID | WO2012068041 | ||||
| Title | 4-Substituted-3-Benzyloxy-Bicyclo[3.1.0]Hexane Compounds As Mglur 2/3 Antagonists. | ||||
| Abstract | A mGlu2/3 receptor antagonist of the formula: (formula), its uses, and methods for its preparation are described. | ||||
| Applicant(s) | Eli Lilly and Company | ||||
| Representative Drug(s) | D01VZE | Drug Info | IC50 = 7.8 nM | Click to Show More | [1] |
| 2 | D0D4OW | Drug Info | IC50 = 27.2 nM | [1] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 - present).Expert Opin Ther Pat. 2015 Jan;25(1):69-90. | ||||
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