miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-9-5p | ||||
miRNA Stemloop AC | MI0000466 | MI0000467 | MI0000468 | ||||
miRNA Stemloop ID | hsa-mir-9-1 | hsa-mir-9-2 | hsa-mir-9-3 | ||||
Sequence | ucuuugguuaucuagcuguauga | ||||
TTD Target(s) Regulated by This miRNA | NT-3 growth factor receptor (TrkC) | Successful Target | Target Info | [1] | |
Beta-secretase 1 (BACE1) | Clinical trial Target | Target Info | [2] | ||
DNA-binding factor KBF1 (p105) | Clinical trial Target | Target Info | [3] | ||
Forkhead box protein O1A (FOXO1) | Literature-reported Target | Target Info | [4] | ||
Epithelial cadherin (CDH1) | Literature-reported Target | Target Info | [5] | ||
Protein(s) Regulated by This miRNA | 5'-3' exoribonuclease 2 | Regulated Protein | [6] | ||
5'-AMP-activated protein kinase catalytic subunit alpha-1 | Regulated Protein | [7] | |||
AP-3 complex subunit beta-1 | Regulated Protein | [8] | |||
Autophagy protein 5 | Regulated Protein | [9] | |||
B-cell lymphoma 6 protein | Regulated Protein | [10] | |||
Bcl-2-like protein 11 | Regulated Protein | [11] | |||
C-1-tetrahydrofolate synthase, cytoplasmic | Regulated Protein | [12] | |||
Charged multivesicular body protein 2b | Regulated Protein | [13] | |||
Cullin-4A | Regulated Protein | [14] | |||
Cyclin-G1 | Regulated Protein | [8] | |||
Cytochrome P450 4Z1 | Regulated Protein | [15] | |||
Cytoplasmic FMR1-interacting protein 2 | Regulated Protein | [16] | |||
Cytoplasmic polyadenylation element-binding protein 4 | Regulated Protein | [16] | |||
Double-stranded RNA-binding protein Staufen homolog 1 | Regulated Protein | [6] | |||
E3 ubiquitin-protein ligase UHRF1 | Regulated Protein | [17] | |||
Endonuclease domain-containing 1 protein | Regulated Protein | [16] | |||
Endoribonuclease ZC3H12A | Regulated Protein | [18] | |||
Forkhead box protein O3 | Regulated Protein | [19] | |||
Forkhead box protein P1 | Regulated Protein | [20] | |||
HMG box-containing protein 1 | Regulated Protein | [16] | |||
Homeobox protein CDX-2 | Regulated Protein | [21] | |||
Insulin-like growth factor 2 mRNA-binding protein 1 | Regulated Protein | [22] | |||
Insulin-like growth factor 2 mRNA-binding protein 3 | Regulated Protein | [23] | |||
Krueppel-like factor 17 | Regulated Protein | [24] | |||
Krueppel-like factor 6 | Regulated Protein | [16] | |||
LHFPL tetraspan subfamily member 2 protein | Regulated Protein | [16] | |||
Myocardin | Regulated Protein | [25] | |||
Neurofibromin | Regulated Protein | [26] | |||
Nuclear receptor subfamily 2 group E member 1 | Regulated Protein | [27] | |||
One cut domain family member 2 | Regulated Protein | [28] | |||
Pituitary homeobox 3 | Regulated Protein | [29] | |||
Polypeptide N-acetylgalactosaminyltransferase 4 | Regulated Protein | [30] | |||
POU domain, class 2, transcription factor 2 | Regulated Protein | [10] | |||
PR domain zinc finger protein 1 | Regulated Protein | [31] | |||
Ras-related protein Rab-34 | Regulated Protein | [32] | |||
Ras-related protein Rab-34 | Regulated Protein | [33] | |||
Ras-related protein Rab-8B | Regulated Protein | [16] | |||
Ras-related protein Rap-2a | Regulated Protein | [34] | |||
RE1-silencing transcription factor | Regulated Protein | [35] | |||
Rho-related GTP-binding protein RhoH | Regulated Protein | [16] | |||
RING1 and YY1-binding protein | Regulated Protein | [16] | |||
Runt-related transcription factor 1 | Regulated Protein | [36] | |||
Serine/arginine-rich splicing factor 1 | Regulated Protein | [6] | |||
Serpin B9 | Regulated Protein | [16] | |||
Serum response factor | Regulated Protein | [37] | |||
StAR-related lipid transfer protein 13 | Regulated Protein | [38] | |||
Suppressor of cytokine signaling 5 | Regulated Protein | [39] | |||
T-cell acute lymphocytic leukemia protein 1 | Regulated Protein | [16] | |||
Trafficking kinesin-binding protein 2 | Regulated Protein | [16] | |||
Transcription factor HES-1 | Regulated Protein | [40] | |||
Transcription factor SOX-7 | Regulated Protein | [41] | |||
Transforming growth factor-beta-induced protein ig-h3 | Regulated Protein | [42] | |||
Transmembrane 4 L6 family member 1 | Regulated Protein | [43] | |||
Tumor necrosis factor alpha-induced protein 8 | Regulated Protein | [44] | |||
Vesicle-associated membrane protein 5 | Regulated Protein | [16] | |||
Vimentin | Regulated Protein | [5] | |||
References | |||||
REF 1 | The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. Proc Natl Acad Sci U S A. 2007 May 8;104(19):7957-62. | ||||
REF 2 | The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci. 2008 Jan 30;28(5):1213-23. | ||||
REF 3 | MicroRNA gene expression during retinoic acid-induced differentiation of human acute promyelocytic leukemia. Oncogene. 2007 Jun 14;26(28):4148-57. | ||||
REF 4 | Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J Biol Chem. 2009 Aug 28;284(35):23204-16. | ||||
REF 5 | miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol. 2010 Mar;12(3):247-56. | ||||
REF 6 | Transcriptome dynamics of the microRNA inhibition response.Nucleic Acids Res. 2015 Jul 27;43(13):6207-21. | ||||
REF 7 | Neuroprotective Effect of Osthole on Neuron Synapses in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9.J Mol Neurosci. 2016 Sep;60(1):71-81. | ||||
REF 8 | MicroRNA-9 inhibition of cell proliferation and identification of novel miR-9 targets by transcriptome profiling in breast cancer cells.J Biol Chem. 2012 Aug 24;287(35):29516-28. | ||||
REF 9 | Noncoding RNA blockade of autophagy is therapeutic in medullary thyroid cancer.Cancer Med. 2015 Feb;4(2):174-82. | ||||
REF 10 | Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation. Leukemia. 2010 Feb;24(2):460-6. | ||||
REF 11 | MicroRNA-9 regulates neural apoptosis in methylmalonic acidemia via targeting BCL2L11.Int J Dev Neurosci. 2014 Aug;36:19-24. | ||||
REF 12 | An NTD-associated polymorphism in the 3' UTR of MTHFD1L can affect disease risk by altering miRNA binding.Hum Mutat. 2014 Jan;35(1):96-104. | ||||
REF 13 | MicroRNA-9 coordinates proliferation and migration of human embryonic stem cell-derived neural progenitors.Cell Stem Cell. 2010 Apr 2;6(4):323-35. | ||||
REF 14 | Cullin 4A (CUL4A), a direct target of miR-9 and miR-137, promotes gastric cancer proliferation and invasion by regulating the Hippo signaling pathway.Oncotarget. 2016 Mar 1;7(9):10037-50. | ||||
REF 15 | CYP4Z1 3'UTR represses migration of human breast cancer cells.Biochem Biophys Res Commun. 2016 Sep 16;478(2):900-7. | ||||
REF 16 | miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia.Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11511-6. | ||||
REF 17 | Regulation of UHRF1 by microRNA-9 modulates colorectal cancer cell proliferation and apoptosis.Cancer Sci. 2015 Jul;106(7):833-9. | ||||
REF 18 | MicroRNA-9 promotion of interleukin-6 expression by inhibiting monocyte chemoattractant protein-induced protein 1 expression in interleukin-1-stimulated human chondrocytes.Arthritis Rheumatol. 2015 May;67(8):2117-28. | ||||
REF 19 | Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis.Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5594-9. | ||||
REF 20 | Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity.Cancer Res. 2014 Mar 1;74(5):1429-39. | ||||
REF 21 | MiR-9 downregulates CDX2 expression in gastric cancer cells.Int J Cancer. 2011 Dec 1;129(11):2611-20. | ||||
REF 22 | Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma.Oncotarget. 2015 Dec 8;6(39):42040-52. | ||||
REF 23 | HDAC inhibitor AR-42 decreases CD44 expression and sensitizes myeloma cells to lenalidomide.Oncotarget. 2015 Oct 13;6(31):31134-50. | ||||
REF 24 | MicroRNA-9 enhances migration and invasion through KLF17 in hepatocellular carcinoma.Mol Oncol. 2013 Oct;7(5):884-94. | ||||
REF 25 | Aberrant Expression of microRNA-9 Contributes to Development of Intracranial Aneurysm by Suppressing Proliferation and Reducing Contractility of Smooth Muscle Cells.Med Sci Monit. 2016 Nov 8;22:4247-4253. | ||||
REF 26 | The CREB-miR-9 negative feedback minicircuitry coordinates the migration and proliferation of glioma cells.PLoS One. 2012;7(11):e49570. | ||||
REF 27 | A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination.Nat Struct Mol Biol. 2009 Apr;16(4):365-71. | ||||
REF 28 | MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells.J Biol Chem. 2006 Sep 15;281(37):26932-42. | ||||
REF 29 | Pseudomonas aeruginosa GroEL Stimulates Production of PTX3 by Activating the NF-B Pathway and Simultaneously Downregulating MicroRNA-9.Infect Immun. 2017 Feb 23;85(3). pii: e00935-16. | ||||
REF 30 | Loss of N-Acetylgalactosaminyltransferase-4 Orchestrates Oncogenic MicroRNA-9 in Hepatocellular Carcinoma.J Biol Chem. 2017 Feb 24;292(8):3186-3200. | ||||
REF 31 | MicroRNA-mediated down-regulation of PRDM1/Blimp-1 in Hodgkin/Reed-Sternberg cells: a potential pathogenetic lesion in Hodgkin lymphomas.Am J Pathol. 2008 Jul;173(1):242-52. | ||||
REF 32 | Down-regulated miR-9 and miR-433 in human gastric carcinoma.J Exp Clin Cancer Res. 2009 Jun 16;28:82. | ||||
REF 33 | MicroRNA profile of paclitaxel-resistant serous ovarian carcinoma based on formalin-fixed paraffin-embedded samples.BMC Cancer. 2013 Apr 30;13:216. | ||||
REF 34 | miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3 pathway by targeting Rap2a.Sci Rep. 2016 May 25;6:26781. | ||||
REF 35 | The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease.J Neurosci. 2008 Dec 31;28(53):14341-6. | ||||
REF 36 | MicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1.J Immunol. 2015 Aug 1;195(3):1301-11. | ||||
REF 37 | Regulation of serum response factor by miRNA-200 and miRNA-9 modulates oligodendrocyte progenitor cell differentiation.Glia. 2012 Dec;60(12):1906-14. | ||||
REF 38 | miR-9 and miR-200 Regulate PDGFR-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer.Cancer Res. 2016 Sep 15;76(18):5562-72. | ||||
REF 39 | Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.EMBO J. 2012 Aug 29;31(17):3513-23. | ||||
REF 40 | Reciprocal Regulation between Bifunctional miR-9/9( and its Transcriptional Modulator Notch in Human Neural Stem Cell Self-Renewal and Differentiation.Stem Cell Reports. 2016 Aug 9;7(2):207-19. | ||||
REF 41 | MiR-9 is involved in TGF-1-induced lung cancer cell invasion and adhesion by targeting SOX7.J Cell Mol Med. 2017 Sep;21(9):2000-2008. | ||||
REF 42 | Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-. J Mol Neurosci. 2012 Feb;46(2):324-35. | ||||
REF 43 | MicroRNA-9 suppresses cell migration and invasion through downregulation of TM4SF1 in colorectal cancer.Int J Oncol. 2016 May;48(5):2135-43. | ||||
REF 44 | MicroRNA-9 inhibits the gastric cancer cell proliferation by targeting TNFAIP8. Cell Prolif. 2017 Apr;50(2). | ||||
REF 45 | miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol. 2010 Mar;12(3):247-56. |
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