miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-874-3p | ||||
miRNA Stemloop AC | MI0005532 | ||||
miRNA Stemloop ID | hsa-mir-874 | ||||
Sequence | cugcccuggcccgagggaccga | ||||
TTD Target(s) Regulated by This miRNA | Histone deacetylase 1 (HDAC1) | Successful Target | Target Info | [1] | |
Signal transducer and activator of transcription 3 (STAT3) | Successful Target | Target Info | [2] | ||
Cyclin-dependent kinase 9 (CDK9) | Clinical trial Target | Target Info | [3] | ||
Rotamase Pin1 (PIN1) | Clinical trial Target | Target Info | [4] | ||
Protein(s) Regulated by This miRNA | Aquaporin-3 | Regulated Protein | [5] | ||
Aquaporin-3 | Regulated Protein | [6] | |||
References | |||||
REF 1 | Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma. Br J Cancer. 2013 Apr 30;108(8):1648-58. | ||||
REF 2 | miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer. Oncotarget. 2015 Jan 30;6(3):1605-17. | ||||
REF 3 | MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9. FEBS Lett. 2014 Dec 20;588(24):4527-35. | ||||
REF 4 | miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression. Oncotarget. 2017 Feb 14;8(7):11343-11355. | ||||
REF 5 | miR-874 Inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer.J Gastroenterol. 2014 Jun;49(6):1011-25. | ||||
REF 6 | MiR-874 promotes intestinal barrier dysfunction through targeting AQP3 following intestinal ischemic injury.FEBS Lett. 2014 Mar 3;588(5):757-63. |
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