miRNA General Information
miRNA Mature ID hsa-miR-661
miRNA Stemloop AC MI0003669
miRNA Stemloop ID hsa-mir-661
Sequence ugccugggucucuggccugcgcgu
TTD Target(s) Regulated by This miRNA O-6-methylguanine-DNA-alkyltransferase (MGMT) Clinical trial Target Target Info [1]
Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Target Info [2]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) Clinical trial Target Target Info [3]
Metastasis associated gene-1 (MTA1) Literature-reported Target Target Info [4]
Protein(s) Regulated by This miRNA Cytochrome c1, heme protein, mitochondrial Regulated Protein [5]
Metastasis-associated protein MTA2 Regulated Protein [4]
Nectin-1 Regulated Protein [7]
Protein Mdm4 Regulated Protein [2]
START domain-containing protein 10 Regulated Protein [7]
Vinculin Regulated Protein [4]
References
REF 1 In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing. Acta Neuropathol. 2013 May;125(5):671-81.
REF 2 miR-661 downregulates both Mdm2 and Mdm4 to activate p53. Cell Death Differ. 2014 Feb;21(2):302-9.
REF 3 A microRNA screen to identify modulators of sensitivity to BCL2 inhibitor ABT-263 (navitoclax). Mol Cancer Ther. 2010 Nov;9(11):2943-50.
REF 4 MicroRNA-661, a c/EBPalpha target, inhibits metastatic tumor antigen 1 and regulates its functions. Cancer Res. 2009 Jul 15;69(14):5639-42.
REF 5 MicroRNA-661 Enhances TRAIL or STS Induced Osteosarcoma Cell Apoptosis by Modulating the Expression of Cytochrome c1.Cell Physiol Biochem. 2017;41(5):1935-1946.
REF 6 MicroRNA-661, a c/EBPalpha target, inhibits metastatic tumor antigen 1 and regulates its functions. Cancer Res. 2009 Jul 15;69(14):5639-42.
REF 7 miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers.Oncogene. 2010 Aug 5;29(31):4436-48.
REF 8 miR-661 downregulates both Mdm2 and Mdm4 to activate p53. Cell Death Differ. 2014 Feb;21(2):302-9.

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