miRNA General Information
miRNA Mature ID hsa-miR-657
miRNA Stemloop AC MI0003681
miRNA Stemloop ID hsa-mir-657
Sequence ggcagguucucacccucucuagg
TTD Target(s) Regulated by This miRNA CI Man-6-P receptor (IGF2R) Clinical trial Target Target Info [1]
Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Target Info [2]
Protein(s) Regulated by This miRNA Transducin-like enhancer protein 1 Regulated Protein [3]
References
REF 1 Allele-specific targeting of hsa-miR-657 to human IGF2R creates a potential mechanism underlying the association of ACAA-insertion/deletion polymorphism with type 2 diabetes. Biochem Biophys Res Commun. 2008 Sep 12;374(1):101-5.
REF 2 Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. Oncogene. 2010 Apr 15;29(15):2302-8.
REF 3 MicroRNA-657 promotes tumorigenesis in hepatocellular carcinoma by targeting transducin-like enhancer protein 1 through nuclear factor kappa B pathways.Hepatology. 2013 May;57(5):1919-30.

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