miRNA General Information
miRNA Mature ID hsa-miR-422a
miRNA Stemloop AC MI0001444
miRNA Stemloop ID hsa-mir-422a
Sequence acuggacuuagggucagaaggc
TTD Target(s) Regulated by This miRNA PI3-kinase alpha (PIK3CA) Successful Target Target Info [1]
Transforming growth factor beta 1 (TGFB1) Successful Target Target Info [2]
Telomerase reverse transcriptase (TERT) Clinical trial Target Target Info [3]
Ecto-5'-nucleotidase (CD73) Clinical trial Target Target Info [4]
Forkhead box protein Q1 (FOXQ1) Literature-reported Target Target Info [5]
Protein(s) Regulated by This miRNA 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase Regulated Protein [6]
Cholesterol 7-alpha-monooxygenase Regulated Protein [6]
Forkhead box protein E1 Regulated Protein [5]
Forkhead box protein G1 Regulated Protein [5]
References
REF 1 MiR-422a acts as a tumor suppressor in glioblastoma by targeting PIK3CA. Am J Cancer Res. 2016 Aug 1;6(8):1695-707.
REF 2 Overexpression of miR-422a inhibits cell proliferation and invasion, and enhances chemosensitivity in osteosarcoma cells. Oncol Rep. 2016 Dec;36(6):3371-3378.
REF 3 Screening and preliminary validation of miRNAs with the regulation of hTERT in colorectal cancer. Oncol Rep. 2015 Jun;33(6):2728-36.
REF 4 MiR-422a promotes loco-regional recurrence by targeting NT5E/CD73 in head and neck squamous cell carcinoma. Oncotarget. 2016 Jul 12;7(28):44023-44038.
REF 5 Double-negative feedback loop between microRNA-422a and forkhead box (FOX)G1/Q1/E1 regulates hepatocellular carcinoma tumor growth and metastasis. Hepatology. 2015 Feb;61(2):561-73.
REF 6 A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes.J Lipid Res. 2010 Aug;51(8):2223-33.
REF 7 Double-negative feedback loop between microRNA-422a and forkhead box (FOX)G1/Q1/E1 regulates hepatocellular carcinoma tumor growth and metastasis. Hepatology. 2015 Feb;61(2):561-73.

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