miRNA General Information
miRNA Mature ID hsa-miR-374a-5p
miRNA Stemloop AC MI0000782
miRNA Stemloop ID hsa-mir-374a
Sequence uuauaauacaaccugauaagug
TTD Target(s) Regulated by This miRNA ATM serine/threonine kinase (ATM) Clinical trial Target Target Info [1]
G1/S-specific cyclin-D1 (CCND1) Clinical trial Target Target Info [2]
Lactate dehydrogenase A (LDHA) Literature-reported Target Target Info [3]
CCAAT/enhancer binding protein beta (CEBPB) Literature-reported Target Target Info [4]
Wnt-5a protein (WNT5A) Literature-reported Target Target Info [5]
Protein(s) Regulated by This miRNA Growth arrest and DNA damage-inducible protein GADD45 alpha Regulated Protein [6]
SRC kinase signaling inhibitor 1 Regulated Protein [7]
Wnt inhibitory factor 1 Regulated Protein [8]
References
REF 1 miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase. Mol Oncol. 2014 Feb;8(1):83-92.
REF 2 Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. Cell. 2010 Apr 2;141(1):129-41.
REF 3 Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer. Oncotarget. 2015 Aug 14;6(23):19456-68.
REF 4 miRNA-374 regulates dexamethasone-induced differentiation of primary cultures of porcine adipocytes. Horm Metab Res. 2013 Jul;45(7):518-25.
REF 5 Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancer. Cell Death Dis. 2014 May 15;5:e1227.
REF 6 Phospho-Np63 is a key regulator of the cisplatin-induced microRNAome in cancer cells. Cell Death Differ. 2011 Jul;18(7):1220-30.
REF 7 miR-374a promotes cell proliferation, migration and invasion by targeting SRCIN1 in gastric cancer.FEBS Lett. 2015 Jan 30;589(3):407-13.
REF 8 MicroRNA-374a activates Wnt/-catenin signaling to promote breast cancer metastasis.J Clin Invest. 2013 Feb;123(2):566-79.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.