miRNA General Information
miRNA Mature ID hsa-miR-326
miRNA Stemloop AC MI0000808
miRNA Stemloop ID hsa-mir-326
Sequence ccucugggcccuuccuccag
TTD Target(s) Regulated by This miRNA Smoothened homolog (SMO) Successful Target Target Info [1]
Programmed cell death 1 ligand 1 (PD-L1) Successful Target Target Info [2]
Apoptosis regulator Bcl-xL (BCL-xL) Clinical trial Target Target Info [3]
Heparin-binding growth factor 1 (FGF1) Clinical trial Target Target Info [4]
Notch-1 receptor (NOTCH1) Clinical trial Target Target Info [5]
Notch-2 receptor (NOTCH2) Clinical trial Target Target Info [5]
Pyruvate kinase M2 (PKM) Clinical trial Target Target Info [6]
Fascin (FSCN1) Clinical trial Target Target Info [7]
Transcription factor Sp1 (SP1) Clinical trial Target Target Info [8]
Zinc finger protein GLI1 (Gli1) Patented-recorded Target Target Info [1]
Leukocyte antigen MIC3 (CD9) Literature-reported Target Target Info [9]
Protein(s) Regulated by This miRNA DNA mismatch repair protein Msh3 Regulated Protein [9]
RNA-binding protein NOB1 Regulated Protein [11]
References
REF 1 Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J. 2008 Oct 8;27(19):2616-27.
REF 2 Identifying microRNAs regulating B7-H3 in breast cancer: the clinical impact of microRNA-29c. Br J Cancer. 2014 Apr 15;110(8):2072-80.
REF 3 miR-326 targets antiapoptotic Bcl-xL and mediates apoptosis in human platelets. PLoS One. 2015 Apr 13;10(4):e0122784.
REF 4 Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326. Oncotarget. 2015 Sep 8;6(26):21934-49.
REF 5 The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. J Neurosci. 2009 Dec 2;29(48):15161-8.
REF 6 Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells. Neuro Oncol. 2010 Nov;12(11):1102-12.
REF 7 Down-regulation of miR-326 is associated with poor prognosis and promotes growth and metastasis by targeting FSCN1 in gastric cancer. Growth Factors. 2015;33(4):267-74.
REF 8 miR-326 reverses chemoresistance in human lung adenocarcinoma cells by targeting specificity protein 1. Tumour Biol. 2016 Oct;37(10):13287-13294.
REF 9 Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1. Biochem Pharmacol. 2010 Mar 15;79(6):817-24.
REF 10 Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1. Biochem Pharmacol. 2010 Mar 15;79(6):817-24.
REF 11 MicroRNA-326 functions as a tumor suppressor in glioma by targeting the Nin one binding protein (NOB1).PLoS One. 2013 Jul 15;8(7):e68469.

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