miRNA General Information
miRNA Mature ID hsa-miR-26b-5p
miRNA Stemloop AC MI0000084
miRNA Stemloop ID hsa-mir-26b
Sequence uucaaguaauucaggauaggu
TTD Target(s) Regulated by This miRNA Cyclin-dependent kinase 6 (CDK6) Successful Target Target Info [1]
Insulin-like growth factor I receptor (IGF1R) Successful Target Target Info [2]
Phosphodiesterase 4A (PDE4A) Successful Target Target Info [3]
ATP-binding cassette transporter A1 (ABCA1) Successful Target Target Info [4]
Prostaglandin G/H synthase 2 (COX-2) Successful Target Target Info [5]
Enhancer of zeste homolog 2 (EZH2) Successful Target Target Info [6]
Hepatocyte growth factor (HGF) Clinical trial Target Target Info [7]
Nicotinamide phosphoribosyltransferase (NAMPT) Clinical trial Target Target Info [8]
Toll-like receptor 4 (TLR4) Clinical trial Target Target Info [9]
Ephrin type-A receptor 2 (EPHA2) Clinical trial Target Target Info [10]
Collagen I (COL1A2) Clinical trial Target Target Info [11]
Connective tissue growth factor (CTGF) Clinical trial Target Target Info [11]
Insulin-like growth factor-I (IGF1) Clinical trial Target Target Info [12]
Phosphatase and tensin homolog (PTEN) Literature-reported Target Target Info [13]
G1/S-specific cyclin-E1 (CCNE1) Literature-reported Target Target Info [1]
Sialyltransferase 8D (ST8SIA4) Literature-reported Target Target Info [14]
GATA-binding factor 4 (GATA4) Literature-reported Target Target Info [15]
Protein(s) Regulated by This miRNA ADP-ribosylation factor-like protein 4C Regulated Protein [16]
Cysteine and histidine-rich domain-containing protein 1 Regulated Protein [17]
Fumarate hydratase, mitochondrial Regulated Protein [18]
Hyaluronan synthase 2 Regulated Protein [19]
Importin subunit alpha-1 Regulated Protein [20]
La-related protein 1 Regulated Protein [21]
Migration and invasion enhancer 1 Regulated Protein [22]
Nuclear receptor subfamily 2 group C member 2 Regulated Protein [23]
Probable ubiquitin carboxyl-terminal hydrolase FAF-X Regulated Protein [24]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 Regulated Protein [25]
Prostaglandin G/H synthase 2 Regulated Protein [26]
Protein jagged-1 Regulated Protein [27]
Retinoblastoma-associated protein Regulated Protein [28]
Serine/threonine-protein kinase ULK2 Regulated Protein [29]
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Regulated Protein [23]
TNF receptor-associated factor 5 Regulated Protein [30]
REF 1 MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Nucleic Acids Res. 2012 May;40(10):4615-25.
REF 2 Modulation of microRNAs in hypertension-induced arterial remodeling through the 1 and 3-adrenoreceptor pathways. J Mol Cell Cardiol. 2013 Dec;65:127-36.
REF 3 Comparative effects of diet and carcinogen on microRNA expression in the stem cell niche of the mouse colonic crypt. Biochim Biophys Acta. 2016 Jan;1862(1):121-34.
REF 4 MicroRNA target prediction by expression analysis of host genes. Genome Res. 2009 Mar;19(3):481-90.
REF 5 MiRNA-26b regulates the expression of cyclooxygenase-2 in desferrioxamine-treated CNE cells. FEBS Lett. 2010 Mar 5;584(5):961-7.
REF 6 Huaier suppresses proliferation and induces apoptosis in human pulmonary cancer cells via upregulation of miR-26b-5p. FEBS Lett. 2014 Jun 5;588(12):2107-14.
REF 7 Exosome-delivered EGFR regulates liver microenvironment to promote gastric cancer liver metastasis. Nat Commun. 2017 Apr 10;8:15016.
REF 8 Nicotinamide phosphoribosyl transferase (Nampt) is a target of microRNA-26b in colorectal cancer cells. PLoS One. 2013 Jul 29;8(7):e69963.
REF 9 Respiratory syncytial virus infection inhibits TLR4 signaling via up-regulation of miR-26b. Cell Biol Int. 2015 Dec;39(12):1376-83.
REF 10 MiR-26b inhibits hepatocellular carcinoma cell proliferation, migration, and invasion by targeting EphA2. Int J Clin Exp Pathol. 2015 May 1;8(5):4782-90.
REF 11 CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts. Sci Rep. 2017 Jan 12;7:40342.
REF 12 MicroRNA-26b is upregulated in a double transgenic mouse model of Alzheimer's disease and promotes the expression of amyloid- by targeting insulin-like growth factor 1. Mol Med Rep. 2016 Mar;13(3):2809-14.
REF 13 The role of microRNA-26b in human adipocyte differentiation and proliferation. Gene. 2014 Jan 10;533(2):481-7.
REF 14 Functional roles of sialylation in breast cancer progression through miR-26a/26b targeting ST8SIA4. Cell Death Dis. 2016 Dec 29;7(12):e2561.
REF 15 GATA4 expression is primarily regulated via a miR-26b-dependent post-transcriptional mechanism during cardiac hypertrophy. Cardiovasc Res. 2012 Mar 15;93(4):645-54.
REF 16 MiR-26 controls LXR-dependent cholesterol efflux by targeting ABCA1 and ARL7. FEBS Lett. 2012 May 21;586(10):1472-9.
REF 17 MicroRNA-26b inhibits hepatitis B virus transcription and replication by targeting the host factor CHORDC1 protein.J Biol Chem. 2014 Dec 12;289(50):35029-41.
REF 18 Mcl-1 Is a Novel Target of miR-26b That Is Associated with the Apoptosis Induced by TRAIL in HCC Cells.Biomed Res Int. 2015;2015:572738.
REF 19 Conserved miR-26b enhances ovarian granulosa cell apoptosis through HAS2-HA-CD44-Caspase-3 pathway by targeting HAS2.Sci Rep. 2016 Feb 18;6:21197.
REF 20 MiR-26b/KPNA2 axis inhibits epithelial ovarian carcinoma proliferation and metastasis through downregulating OCT4.Oncotarget. 2015 Sep 15;6(27):23793-806.
REF 21 MicroRNA-26a/b directly regulate La-related protein 1 and inhibit cancer cell invasion in prostate cancer.Int J Oncol. 2015 Aug;47(2):710-8.
REF 22 MicroRNA-26b suppresses the metastasis of non-small cell lung cancer by targeting MIEN1 via NF-B/MMP-9/VEGF pathways.Biochem Biophys Res Commun. 2016 Apr 8;472(3):465-70.
REF 23 MicroRNA-26b suppresses the NF-B signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3.Mol Cancer. 2014 Feb 24;13:35.
REF 24 MicroRNA-26b inhibits epithelial-mesenchymal transition in hepatocellular carcinoma by targeting USP9X.BMC Cancer. 2014 Jun 2;14:393.
REF 25 Tumour-suppressive miRNA-26a-5p and miR-26b-5p inhibit cell aggressiveness by regulating PLOD2 in bladder cancer.Br J Cancer. 2016 Jul 26;115(3):354-63.
REF 26 miR-26b is downregulated in human tongue squamous cell carcinoma and regulates cell proliferation and metastasis through a COX-2-dependent mechanism.Oncol Rep. 2015 Feb;33(2):974-80.
REF 27 Down-regulation of miR-26b induces cisplatin resistance in nasopharyngeal carcinoma by repressing JAG1.FEBS Open Bio. 2016 Oct 24;6(12):1211-1219.
REF 28 MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons.J Neurosci. 2013 Sep 11;33(37):14645-59.
REF 29 MiR-26b inhibits autophagy by targeting ULK2 in prostate cancer cells.Biochem Biophys Res Commun. 2016 Mar 25;472(1):194-200.
REF 30 MiR-26b inhibits melanoma cell proliferation and enhances apoptosis by suppressing TRAF5-mediated MAPK activation.Biochem Biophys Res Commun. 2016 Mar 11;471(3):361-7.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.