miRNA General Information
miRNA Mature ID hsa-miR-221-5p
miRNA Stemloop AC MI0000298
miRNA Stemloop ID hsa-mir-221
Sequence accuggcauacaauguagauuu
TTD Target(s) Regulated by This miRNA CDK inhibitor 1B p27Kip1 (CDKN1B) Literature-reported Target Target Info [1]
CDK inhibitor 1C p57Kip2 (CDKN1C) Literature-reported Target Target Info [1]
Runt-related transcription factor 2 (RUNX2) Literature-reported Target Target Info [2]
Protein(s) Regulated by This miRNA Interleukin-6 receptor subunit alpha Regulated Protein [3]
Methyl-CpG-binding domain protein 2 Regulated Protein [4]
Sjoegren syndrome/scleroderma autoantigen 1 Regulated Protein [5]
References
REF 1 Epstein-Barr Virus Proteins EBNA3A and EBNA3C Together Induce Expression of the Oncogenic MicroRNA Cluster miR-221/miR-222 and Ablate Expression of Its Target p57KIP2. PLoS Pathog. 2015 Jul 8;11(7):e1005031.
REF 2 MicroRNA-221 is involved in the regulation of osteoporosis through regulates RUNX2 protein expression and osteoblast differentiation. Am J Transl Res. 2017 Jan 15;9(1):126-135.
REF 3 Identification of a novel substance P (SP)-neurokinin-1 receptor (NK-1R) microRNA-221-5p inflammatory network in human colonic epithelial cells.Cell Mol Gastroenterol Hepatol. 2015 Sep 1;1(5):503-515.
REF 4 Decreased levels of miR-224 and the passenger strand of miR-221 increase MBD2, suppressing maspin and promoting colorectal tumor growth and metastasis in mice.Gastroenterology. 2013 Oct;145(4):853-64.e9.
REF 5 Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells.PLoS One. 2015 May 8;10(5):e0125779.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.