miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-21-3p | ||||
miRNA Stemloop AC | MI0000077 | ||||
miRNA Stemloop ID | hsa-mir-21 | ||||
Sequence | caacaccagucgaugggcugu | ||||
TTD Target(s) Regulated by This miRNA | Signal transducer and activator of transcription 3 (STAT3) | Successful Target | Target Info | [1] | |
Phosphatase and tensin homolog (PTEN) | Literature-reported Target | Target Info | [2] | ||
Apoptosis antigen ligand (CD178) | Literature-reported Target | Target Info | [3] | ||
Protein(s) Regulated by This miRNA | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Regulated Protein | [4] | ||
Methionine adenosyltransferase 2 subunit beta | Regulated Protein | [5] | |||
Neural cell adhesion molecule L1 | Regulated Protein | [6] | |||
Programmed cell death protein 4 | Regulated Protein | [7] | |||
Programmed cell death protein 4 | Regulated Protein | [8] | |||
RCC1 and BTB domain-containing protein 1 | Regulated Protein | [9] | |||
RNA-binding protein with multiple splicing | Regulated Protein | [9] | |||
S-adenosylmethionine synthase isoform type-2 | Regulated Protein | [5] | |||
Zinc finger protein 350 | Regulated Protein | [10] | |||
Zinc finger protein 608 | Regulated Protein | [9] | |||
References | |||||
REF 1 | Effects of microRNA-21 on the biological functions of T-cell acute lymphoblastic lymphoma/leukemia. Oncol Lett. 2016 Nov;12(5):4173-4180. | ||||
REF 2 | Overexpression of miR-21 promotes the proliferation and migration of cervical cancer cells via the inhibition of PTEN. Oncol Rep. 2015 Jun;33(6):3108-16. | ||||
REF 3 | MiR-21 up-regulation mediates glioblastoma cancer stem cells apoptosis and proliferation by targeting FASLG. Mol Biol Rep. 2015 Mar;42(3):721-7. | ||||
REF 4 | MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma.BMC Cancer. 2016 Aug 25;16(1):685. | ||||
REF 5 | MicroRNA-21-3p, a berberine-induced miRNA, directly down-regulates human methionine adenosyltransferases 2A and 2B and inhibits hepatoma cell growth.PLoS One. 2013 Sep 30;8(9):e75628. | ||||
REF 6 | Human microRNA expression in sporadic and FAP-associated desmoid tumors and correlation with beta-catenin mutations.Oncotarget. 2017 Jun 27;8(26):41866-41875. | ||||
REF 7 | ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism.Oncotarget. 2016 Jan 12;7(2):1439-50. | ||||
REF 8 | Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells.J Cancer. 2017 Jan 1;8(1):57-64. | ||||
REF 9 | Targeting miR-21-3p inhibits proliferation and invasion of ovarian cancer cells.Oncotarget. 2016 Jun 14;7(24):36321-36337. | ||||
REF 10 | Functional SNP in 3'-UTR MicroRNA-Binding Site of ZNF350 Confers Risk for Age-Related Cataract.Hum Mutat. 2016 Nov;37(11):1223-1230. |
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