miRNA General Information
miRNA Mature ID hsa-miR-21-3p
miRNA Stemloop AC MI0000077
miRNA Stemloop ID hsa-mir-21
Sequence caacaccagucgaugggcugu
TTD Target(s) Regulated by This miRNA Signal transducer and activator of transcription 3 (STAT3) Successful Target Target Info [1]
Phosphatase and tensin homolog (PTEN) Literature-reported Target Target Info [2]
Apoptosis antigen ligand (CD178) Literature-reported Target Target Info [3]
Protein(s) Regulated by This miRNA 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Regulated Protein [4]
Methionine adenosyltransferase 2 subunit beta Regulated Protein [5]
Neural cell adhesion molecule L1 Regulated Protein [6]
Programmed cell death protein 4 Regulated Protein [7]
Programmed cell death protein 4 Regulated Protein [8]
RCC1 and BTB domain-containing protein 1 Regulated Protein [9]
RNA-binding protein with multiple splicing Regulated Protein [9]
S-adenosylmethionine synthase isoform type-2 Regulated Protein [5]
Zinc finger protein 350 Regulated Protein [10]
Zinc finger protein 608 Regulated Protein [9]
References
REF 1 Effects of microRNA-21 on the biological functions of T-cell acute lymphoblastic lymphoma/leukemia. Oncol Lett. 2016 Nov;12(5):4173-4180.
REF 2 Overexpression of miR-21 promotes the proliferation and migration of cervical cancer cells via the inhibition of PTEN. Oncol Rep. 2015 Jun;33(6):3108-16.
REF 3 MiR-21 up-regulation mediates glioblastoma cancer stem cells apoptosis and proliferation by targeting FASLG. Mol Biol Rep. 2015 Mar;42(3):721-7.
REF 4 MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma.BMC Cancer. 2016 Aug 25;16(1):685.
REF 5 MicroRNA-21-3p, a berberine-induced miRNA, directly down-regulates human methionine adenosyltransferases 2A and 2B and inhibits hepatoma cell growth.PLoS One. 2013 Sep 30;8(9):e75628.
REF 6 Human microRNA expression in sporadic and FAP-associated desmoid tumors and correlation with beta-catenin mutations.Oncotarget. 2017 Jun 27;8(26):41866-41875.
REF 7 ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism.Oncotarget. 2016 Jan 12;7(2):1439-50.
REF 8 Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells.J Cancer. 2017 Jan 1;8(1):57-64.
REF 9 Targeting miR-21-3p inhibits proliferation and invasion of ovarian cancer cells.Oncotarget. 2016 Jun 14;7(24):36321-36337.
REF 10 Functional SNP in 3'-UTR MicroRNA-Binding Site of ZNF350 Confers Risk for Age-Related Cataract.Hum Mutat. 2016 Nov;37(11):1223-1230.

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