miRNA Details
miRNA General Information | |||||
---|---|---|---|---|---|
miRNA Mature ID | hsa-miR-196a-5p | ||||
miRNA Stemloop AC | MI0000238 | MI0000279 | ||||
miRNA Stemloop ID | hsa-mir-196a-1 | hsa-mir-196a-2 | ||||
Sequence | uagguaguuucauguuguuggg | ||||
TTD Target(s) Regulated by This miRNA | Inhibitor of nuclear factor kappa-B kinase beta (IKKB) | Clinical trial Target | Target Info | [1] | |
Calgranulin B (S100A9) | Clinical trial Target | Target Info | [2] | ||
Homeobox protein Hox-A7 (HOXA7) | Literature-reported Target | Target Info | [3] | ||
Protein(s) Regulated by This miRNA | Annexin A1 | Regulated Protein | [4] | ||
Elongation of very long chain fatty acids protein 1 | Regulated Protein | [5] | |||
Homeobox protein Hox-A10 | Regulated Protein | [6] | |||
Homeobox protein Hox-B7 | Regulated Protein | [7] | |||
Homeobox protein Hox-B8 | Regulated Protein | [8] | |||
Homeobox protein Hox-C8 | Regulated Protein | [9] | |||
Homeobox protein Hox-D8 | Regulated Protein | [8] | |||
Keratin, type II cytoskeletal 5 | Regulated Protein | [2] | |||
Lethal(2) giant larvae protein homolog 1 | Regulated Protein | [11] | |||
Lymphocyte-specific protein 1 | Regulated Protein | [12] | |||
MAM domain-containing protein 2 | Regulated Protein | [13] | |||
Netrin-4 | Regulated Protein | [14] | |||
NF-kappa-B inhibitor alpha | Regulated Protein | [15] | |||
Radixin | Regulated Protein | [16] | |||
Sjoegren syndrome/scleroderma autoantigen 1 | Regulated Protein | [17] | |||
References | |||||
REF 1 | Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells. Oncogene. 2008 Aug 7;27(34):4712-23. | ||||
REF 2 | MicroRNA-196a is a potential marker of progression during Barrett's metaplasia-dysplasia-invasive adenocarcinoma sequence in esophagus. Am J Pathol. 2009 May;174(5):1940-8. | ||||
REF 3 | MicroRNA-directed cleavage of HOXB8 mRNA. Science. 2004 Apr 23;304(5670):594-6. | ||||
REF 4 | MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers.Oncogene. 2008 Nov 6;27(52):6667-78. | ||||
REF 5 | MicroRNA Profiling Identifies miR-196a as Differentially Expressed in Childhood Adrenoleukodystrophy and Adult Adrenomyeloneuropathy.Mol Neurobiol. 2017 Mar;54(2):1392-1403. | ||||
REF 6 | Expression and mechanism of action of miR-196a in epithelial ovarian cancer.Asian Pac J Trop Med. 2016 Nov;9(11):1105-1110. | ||||
REF 7 | MicroRNA miR-196a is a central regulator of HOX-B7 and BMP4 expression in malignant melanoma.Cell Mol Life Sci. 2010 Oct;67(20):3535-48. | ||||
REF 8 | High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells.World J Gastroenterol. 2009 May 7;15(17):2089-96. | ||||
REF 9 | miR-196a regulates proliferation and osteogenic differentiation in mesenchymal stem cells derived from human adipose tissue.J Bone Miner Res. 2009 May;24(5):816-25. | ||||
REF 10 | MicroRNA-196a is a potential marker of progression during Barrett's metaplasia-dysplasia-invasive adenocarcinoma sequence in esophagus. Am J Pathol. 2009 May;174(5):1940-8. | ||||
REF 11 | MicroRNA miR-196a controls melanoma-associated genes by regulating HOX-C8 expression.Int J Cancer. 2011 Sep 1;129(5):1064-74. | ||||
REF 12 | Genetic variations in microRNAs and the risk and survival of renal cell cancer.Carcinogenesis. 2014 Jul;35(7):1629-35. | ||||
REF 13 | The role of HOXB9 and miR-196a in head and neck squamous cell carcinoma.PLoS One. 2015 Apr 10;10(4):e0122285. | ||||
REF 14 | miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells.Biochem Biophys Res Commun. 2013 Nov 1;440(4):582-8. | ||||
REF 15 | MiR-196a promotes pancreatic cancer progression by targeting nuclear factor kappa-B-inhibitor alpha.PLoS One. 2014 Feb 4;9(2):e87897. | ||||
REF 16 | MicroRNA-196a/-196b promote cell metastasis via negative regulation of radixin in human gastric cancer.Cancer Lett. 2014 Sep 1;351(2):222-31. | ||||
REF 17 | Upregulation of MiR-196a promotes cell proliferation by downregulating p27kip1 in laryngeal cancer.Biol Res. 2016 Sep 27;49(1):40. |
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