miRNA General Information
miRNA Mature ID hsa-miR-127-3p
miRNA Stemloop AC MI0000472
miRNA Stemloop ID hsa-mir-127
Sequence ucggauccgucugagcuuggcu
TTD Target(s) Regulated by This miRNA PI3-kinase gamma (PIK3CG) Successful Target Target Info [1]
Matrix metalloproteinase-13 (MMP-13) Clinical trial Target Target Info [2]
O-6-methylguanine-DNA-alkyltransferase (MGMT) Clinical trial Target Target Info [3]
SET domain containing 8 (KMT5A) Preclinical Target Target Info [4]
Protein(s) Regulated by This miRNA B-cell lymphoma 6 protein Regulated Protein [5]
BAG family molecular chaperone regulator 5 Regulated Protein [6]
DNA repair protein XRCC3 Regulated Protein [7]
Mitogen-activated protein kinase 4 Regulated Protein [8]
PR domain zinc finger protein 1 Regulated Protein [9]
Repulsive guidance molecule A Regulated Protein [10]
Secreted frizzled-related protein 1 Regulated Protein [10]
Septin-7 Regulated Protein [11]
Serpin B9 Regulated Protein [10]
Ski oncogene Regulated Protein [10]
X-box-binding protein 1 Regulated Protein [9]
ZW10 interactor Regulated Protein [10]
References
REF 1 Pulmonary microRNA expression profiling in an immature piglet model of cardiopulmonary bypass-induced acute lung injury. Artif Organs. 2015 Apr;39(4):327-35.
REF 2 A feedback inhibition between miRNA-127 and TGF/c-Jun cascade in HCC cell migration via MMP13. PLoS One. 2013 Jun 7;8(6):e65256.
REF 3 miRNA array screening reveals cooperative MGMT-regulation between miR-181d-5p and miR-409-3p in glioblastoma. Oncotarget. 2016 May 10;7(19):28195-206.
REF 4 Down-regulation of MiR-127 facilitates hepatocyte proliferation during rat liver regeneration. PLoS One. 2012;7(6):e39151.
REF 5 CpG island hypermethylation of tumor suppressor microRNAs in human cancer.Cell Cycle. 2007 Jun 15;6(12):1455-9.
REF 6 MicroRNA-127-3p acts as a tumor suppressor in epithelial ovarian cancer by regulating the BAG5 gene.Oncol Rep. 2016 Nov;36(5):2563-2570.
REF 7 MiroRNA-127-3p targets XRCC3 to enhance the chemosensitivity of esophageal cancer cells to a novel phenanthroline-dione derivative.Int J Biochem Cell Biol. 2016 Oct;79:158-167.
REF 8 The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer.Int J Mol Sci. 2013 Jul 8;14(7):14171-84.
REF 9 B-cell differentiation in EBV-positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA-altered expression.Int J Cancer. 2010 Mar 15;126(6):1316-26.
REF 10 Next generation sequencing analysis of miRNAs: MiR-127-3p inhibits glioblastoma proliferation and activates TGF- signaling by targeting SKI.OMICS. 2014 Mar;18(3):196-206.
REF 11 MicroRNA-127-3p promotes glioblastoma cell migration and invasion by targeting the tumor-suppressor gene SEPT7.Oncol Rep. 2014 May;31(5):2261-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.