miRNA General Information
miRNA Mature ID hsa-miR-105-5p
miRNA Stemloop AC MI0000111 | MI0000112
miRNA Stemloop ID hsa-mir-105-1 | hsa-mir-105-2
Sequence ucaaaugcucagacuccuguggu
TTD Target(s) Regulated by This miRNA Toll-like receptor 2 (TLR2) Clinical trial Target Target Info [1]
Protein(s) Regulated by This miRNA Nuclear receptor coactivator 1 Regulated Protein [2]
Tight junction protein ZO-1 Regulated Protein [3]
Transcription factor SOX-9 Regulated Protein [4]
References
REF 1 Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes. J Biol Chem. 2009 Aug 21;284(34):23107-15.
REF 2 High expression of miR-105-1 positively correlates with clinical prognosis of hepatocellular carcinoma by targeting oncogene NCOA1.Oncotarget. 2017 Feb 14;8(7):11896-11905.
REF 3 Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis.Cancer Cell. 2014 Apr 14;25(4):501-15.
REF 4 MicroRNA-105 targets SOX9 and inhibits human glioma cell progression.FEBS Lett. 2016 Dec;590(23):4329-4342.

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