miRNA General Information
miRNA Mature ID hsa-let-7d-5p
miRNA Stemloop AC MI0000065
miRNA Stemloop ID hsa-let-7d
Sequence agagguaguagguugcauaguu
TTD Target(s) Regulated by This miRNA Amyloid beta A4 protein (APP) Successful Target Target Info [1]
Thrombopoietin receptor (MPL) Successful Target Target Info [2]
Interleukin-13 (IL13) Successful Target Target Info [3]
TRAIL receptor 2 (TRAIL-R2) Clinical trial Target Target Info [4]
Platelet-derived growth factor A (PDGFA) Clinical trial Target Target Info [5]
Divalent metal transporter 1 (SLC11A2) Literature-reported Target Target Info [6]
High mobility group protein HMGI-C (HMGA2) Literature-reported Target Target Info [7]
Protein(s) Regulated by This miRNA Collagen alpha-1(III) chain Regulated Protein [8]
Protein argonaute-1 Regulated Protein [9]
REF 1 MicroRNA regulation of Alzheimer's Amyloid precursor protein expression. Neurobiol Dis. 2009 Mar;33(3):422-8.
REF 2 miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets. Blood. 2010 Jul 22;116(3):437-45.
REF 3 Let-7 microRNA-mediated regulation of IL-13 and allergic airway inflammation. J Allergy Clin Immunol. 2011 Nov;128(5):1077-85.e1-10.
REF 4 Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells. Gastroenterology. 2014 Jan;146(1):278-90.
REF 5 PDGF induced microRNA alterations in cancer cells. Nucleic Acids Res. 2011 May;39(10):4035-47.
REF 6 Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells. Haematologica. 2010 Aug;95(8):1244-52.
REF 7 Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2. Cell Cycle. 2007 Nov 1;6(21):2585-90.
REF 8 Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7.Mol Cancer. 2014 Sep 6;13:206.
REF 9 Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis.J Clin Invest. 2013 Mar;123(3):1057-67.

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