Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T99948 | ||||
| Target Name | Programmed cell death 1 ligand 1 (PD-L1) | ||||
| Synonyms | hPD-L1; Programmed death ligand 1; PDL1; PDCD1LG1; PDCD1L1; PDCD1 ligand 1; B7H1; B7-H1; B7 homolog 1 | ||||
| Target Type | Successful | ||||
| Gene Name | CD274 | ||||
| Biochemical Class | Immunoglobulin | ||||
| UniProt ID | PD1L1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Bladder cancer | ||||
| Example drug | RG-7446 | Phase 3 | [1], [2] | ||
| Tissue | Bladder tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.37 Z-score: 2.1 P-value: 4.38E-07 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| References | |||||
| REF 1 | 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76. | ||||
| REF 2 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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