Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T92687 | ||||
| Target Name | Gastric H(+)/K(+) ATPase (Proton pump) | ||||
| Synonyms | Proton pump; Potassium-transporting ATPase | ||||
| Target Type | Successful | ||||
| Gene Name | ATP4A; ATP4B | ||||
| UniProt ID | ATP4A_HUMAN||ATP4B_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Eosinophilic gastritis | ||||
| Example drug | AZD-0865 | Phase 2 | [1], [2], [3] | ||
| Tissue | Gastric antrum tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section |
Fold-change: -0.88 Z-score: -0.44 P-value: 7.17E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Disease | Ulcerative colitis | ||||
| Example drug | LEMINOPRAZOLE | Discontinued in Preregistration | [2], [3], [4] | ||
| Tissue | Colon mucosal tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section |
Fold-change: 0.08 Z-score: 0.38 P-value: 2.18E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00206284) A Dose-finding Phase IIb Study With AZD0865 and Esomeprazole in GERD Patients Without Erosive Esophagitis.. U.S. National Institutes of Health. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 4 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000604) | ||||
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