Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T91023 | ||||
| Target Name | Roof plate-specific spondin-1 (RSPO1) | ||||
| Synonyms | hRspo1; R-spondin-1 | ||||
| Target Type | Clinical trial | ||||
| Gene Name | RSPO1 | ||||
| UniProt ID | RSPO1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Eosinophilic gastritis | ||||
| Example drug | NU-206 | Phase 1 | [1], [2], [3] | ||
| Tissue | Gastric antrum tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section |
Fold-change: -0.01 Z-score: -0.26 P-value: 4.37E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| References | |||||
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3697). | ||||
| REF 2 | R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14700-5. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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