Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T86652 | ||||
| Target Name | PCSK9 messenger RNA (PCSK9 mRNA) | ||||
| Synonyms | Subtilisin/kexin-like protease PC9 (mRNA); Proprotein convertase subtilisin/kexin type 9 (mRNA); Proprotein convertase 9 (mRNA); PSEC0052 (mRNA); PC9 (mRNA); Neural apoptosis-regulated convertase 1 (mRNA); NARC1 (mRNA); NARC-1 (mRNA) | ||||
| Target Type | Successful | ||||
| Gene Name | PCSK9 | ||||
| Biochemical Class | mRNA target | ||||
| UniProt ID | PCSK9_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Coronary artery disease | ||||
| Example drug | BMS-PCSK9 | Preclinical | [1], [2] | ||
| Tissue | Peripheral blood | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.13 Z-score: -0.62 P-value: 9.13E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Familial hypercholesterolemia | ||||
| Example drug | ALN-PCS | Preclinical | [2], [3] | ||
| Tissue | Whole blood | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.07 Z-score: -0.3 P-value: 4.82E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| References | |||||
| REF 1 | Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011). | ||||
| REF 2 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 3 | Clinical pipeline report, company report or official report of Alnylam Pharmaceuticals, Inc (2011). | ||||
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