Target's General Information
Target ID T78198
Target Name Purine nucleoside phosphorylase (PNP)
Synonyms PNP; Inosine phosphorylase
Target Type Clinical trial
Gene Name PNP
Biochemical Class Pentosyltransferase
UniProt ID PNPH_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Psoriasis
Example drug BCX-4208 Phase 2 [1], [2], [3]
Tissue Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 1.43
Z-score: 2.13
P-value: 3.50E-25
Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section Fold-change: 1.37
Z-score: 3.25
P-value: 3.23E-40
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Disease Rheumatoid arthritis
Tissue Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 1.95
Z-score: 2.55
P-value: 3.67E-04
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 ClinicalTrials.gov (NCT01407874) A Randomized, Double-Blind, Dose-Response Study of the Safety and Uric Acid Effects of Oral Ulodesine Added to Allopurinol in Subjects With Gout and Concomitant Moderate Renal Insufficiency. U.S. National Institutes of Health.
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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