Target's General Information
Target ID T67894
Target Name Toll-like receptor 3 (TLR3)
Synonyms CD283
Target Type Clinical trial
Gene Name TLR3
Biochemical Class Toll-like receptor
UniProt ID TLR3_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Glioma
Example drug Poly-ICLC Phase 2 [1], [2], [3]
Tissue Brainstem tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.63
Z-score: 0.83
P-value: 4.85E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Glioma
Example drug Poly-ICLC Phase 2 [1], [2], [3]
Tissue White matter
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.11
Z-score: 0.1
P-value: 8.00E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med. 2007 Feb 12;5:10.
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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