Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T55922 | ||||
| Target Name | S-adenosylmethionine decarboxylase proenzyme (AMD1) | ||||
| Synonyms | SamDC; S-adenosylmethioninedecarboxylase; AdoMetDC; AMD | ||||
| Target Type | Successful | ||||
| Gene Name | AMD1 | ||||
| Biochemical Class | Carbon-carbon lyase | ||||
| UniProt ID | DCAM_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Head and neck cancer | ||||
| Example drug | MGBG | Terminated | [1], [2], [3], [4] | ||
| Tissue | Head and neck tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.37 Z-score: 0.61 P-value: 4.41E-05 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77. | ||||
| REF 2 | Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs. Mol Pharmacol. 2001 Feb;59(2):231-8. | ||||
| REF 3 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 4 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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