Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T46628 | ||||
| Target Name | Microsomal triglyceride transfer protein (MTTP) | ||||
| Synonyms | Microsomal triglyceride transfer protein large subunit; MTP | ||||
| Target Type | Successful | ||||
| Gene Name | MTTP | ||||
| UniProt ID | MTP_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Familial hypercholesterolemia | ||||
| Example drug | Lomitapide | Approved | [1], [2], [3], [4] | ||
| Tissue | Whole blood | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.15 Z-score: -0.71 P-value: 2.59E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Arteriosclerosis | ||||
| Example drug | GR-328713 | Discontinued in Phase 1 | [5], [3], [4] | ||
| Tissue | Peripheral blood | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.07 Z-score: 1.33 P-value: 2.25E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Type 2 diabetes | ||||
| Example drug | JNJ-16269110 | Phase 2 | [6], [3], [4] | ||
| Tissue | Liver tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.13 Z-score: 0.68 P-value: 9.76E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7439). | ||||
| REF 2 | Nat Rev Drug Discov. 2013 Feb;12(2):87-90. | ||||
| REF 3 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 4 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
| REF 5 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008868) | ||||
| REF 6 | ClinicalTrials.gov (NCT00672386) A Study of the Safety and Effectiveness of a R256918 in Patients With Type 2 Diabetes. U.S. National Institutes of Health. | ||||
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