Target's General Information
Target ID T45612
Target Name B7 homolog 3 (CD276)
Synonyms UNQ309/PRO352; PSEC0249; Costimulatory molecule; CD276 antigen; B7H3; B7-H3; 4IgB7H3; 4Ig-B7-H3
Target Type Clinical trial
Gene Name CD276
Biochemical Class Immunoglobulin
UniProt ID CD276_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Glioma
Example drug 124I-8H9 Phase 1 [1], [2]
Tissue Brainstem tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.04
Z-score: -0.81
P-value: 3.92E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Glioma
Example drug 124I-8H9 Phase 1 [1], [2]
Tissue White matter
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.53
Z-score: -1.33
P-value: 7.33E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
References
REF 1 ClinicalTrials.gov (NCT01099644) Intraperitoneal Radioimmunotherapy With 131I-8H9 for Patients With Desmoplastic Small Round Cell Tumors and Other Solid Tumors Involving the Peritoneum. U.S. NationalInstitutes of Health.
REF 2 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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