Target's General Information
Target ID T31621
Target Name Fibroblast growth factor-2 (FGF2)
Synonyms bFGF; Heparin-binding growth factor 2; HBGF-2; Fibroblast growth factor 2; FGFB; FGF-2; Basic fibroblast growth factor
Target Type Successful
Gene Name FGF2
Biochemical Class Growth factor
UniProt ID FGF2_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Arteriosclerosis
Example drug DVC1-0101 Phase 2 [1], [2], [3]
Tissue Peripheral blood
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -1.67E-03
Z-score: -0.02
P-value: 5.52E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Myeloma
Tissue Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.05
Z-score: 0.3
P-value: 6.36E-03
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 DVC1-0101 to treat peripheral arterial disease: a Phase I/IIa open-label dose-escalation clinical trial. Mol Ther. 2013 Mar;21(3):707-14.
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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