Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T30985 | ||||
| Target Name | Histamine H2 receptor (H2R) | ||||
| Synonyms | Histamine receptor 2; HH2R; Gastric receptor I | ||||
| Target Type | Successful | ||||
| Gene Name | HRH2 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | HRH2_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Ulcerative colitis | ||||
| Example drug | Pibutidine | Discontinued in Phase 3 | [1], [2], [3] | ||
| Tissue | Colon mucosal tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue section of the tissue adjacent to the disease section |
Fold-change: 0.19 Z-score: 0.36 P-value: 2.78E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000641) | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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