Target's General Information
Target ID T28226
Target Name GTP cyclohydrolase-I (GCH1)
Synonyms Guanosine triphosphate cyclohydrolase I; GTP-CH-I; GTP cyclohydrolase I; GTP cyclohydrolase 1; GCH; DYT5
Target Type Clinical trial
Gene Name GCH1
Biochemical Class Carbon-nitrogen hydrolase
UniProt ID GCH1_HUMAN
Target's Expression Profile in Disease Related Tissue between Patients and Normal People
Disease Parkinson's disease
Example drug ProSavin Phase 1/2 [1], [2], [3]
Tissue Substantia nigra tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -1.59
Z-score: -1.53
P-value: 3.38E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target's Expression Profile across Various Tissues of Healthy Individual
References
REF 1 ClinicalTrials.gov (NCT01856439) Long Term Safety and Efficacy Study of ProSavin in Parkinson's Disease. U.S. National Institutes of Health.
REF 2 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
REF 3 NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5.

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