Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T27376 | ||||
| Target Name | GABA(A) receptor delta (GABRD) | ||||
| Synonyms | Gammaaminobutyric acid receptor subunit delta; GABRD; GABA(A) receptor subunit delta | ||||
| Target Type | Successful | ||||
| Gene Name | GABRD | ||||
| Biochemical Class | Ligand-gated ion channel | ||||
| UniProt ID | GBRD_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Epilepsy | ||||
| Example drug | Ganaxolone | Phase 2 | [1], [2], [3] | ||
| Tissue | Peritumoral cortex tissue | ||||
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Depression | ||||
| Tissue | Pre-frontal cortex | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.14 Z-score: -0.19 P-value: 7.17E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 2009 Jan;83(1):1-43. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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