Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T22583 | ||||
| Target Name | Sodium/glucose cotransporter 2 (SLC5A4) | ||||
| Synonyms | Sodium/glucose cotransporter 4; SLC5A4 | ||||
| Target Type | Clinical trial | ||||
| Gene Name | SLC5A4 | ||||
| Biochemical Class | Solute:sodium symporter | ||||
| UniProt ID | SC5A2_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Type 2 diabetes | ||||
| Example drug | RG7201 | Phase 3 | [1], [2], [3] | ||
| Tissue | Liver tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.09 Z-score: -0.37 P-value: 3.26E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study. Cardiovasc Diabetol. 2014 Mar 28;13:65. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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