Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T20808 | ||||
| Target Name | Isocitrate dehydrogenase (IDH) | ||||
| Synonyms | Isocitrate dehydrogenase [NAD] | ||||
| Target Type | Successful | ||||
| Gene Name | IDH1; IDH2; IDH3A; IDH3B; IDH3G | ||||
| Biochemical Class | CH-OH donor oxidoreductase | ||||
| UniProt ID | IDHP_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Acute myelocytic leukemia | ||||
| Example drug | AG-221 | Phase 1/2 | [1], [2], [3] | ||
| Tissue | Bone marrow | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.11 Z-score: 0.24 P-value: 6.06E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | ClinicalTrials.gov (NCT02273739) Study of Orally Administered AG-221 in Subjects With Advanced Solid Tumors, Including Glioma, and With Angioimmunoblastic T-cell Lymphoma, With an IDH2 Mutation. U.S.National Institutes of Health. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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