Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T19433 | ||||
| Target Name | Glutathione-dependent PGD synthase (HPGDS) | ||||
| Synonyms | HPGDS; Glutathione-S-transferase; GST class-alpha | ||||
| Target Type | Successful | ||||
| Gene Name | HPGDS | ||||
| Biochemical Class | Intramolecular oxidoreductases | ||||
| UniProt ID | HPGDS_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Alzheimer's disease | ||||
| Example drug | HF-0220 | Phase 2 | [1], [2], [3] | ||
| Tissue | Entorhinal cortex | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 0.34 Z-score: 0.71 P-value: 1.63E-05 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00357357) European Study of HF0220 in Mild to Moderate Alzheimer's Disease Patients. U.S. National Institutes of Health. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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