Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T18299 | ||||
| Target Name | CaM-kinase II (CAMK2) | ||||
| Synonyms | Calcium/calmodulin-dependent protein kinase type II; CaMK-II; CaM kinase II; CAMK | ||||
| Target Type | Clinical trial | ||||
| Gene Name | CAMK2A; CAMK2B; CAMK2D; CAMK2G | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | KCC2A_HUMAN||KCC2B_HUMAN||KCC2D_HUMAN||KCC2G_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Rheumatoid arthritis | ||||
| Example drug | Rimacalib | Phase 2 | [1], [2], [3] | ||
| Tissue | Synovial tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: -0.33 Z-score: -0.93 P-value: 1.34E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | CaMKII inhibitors: from research tools to therapeutic agents. Front Pharmacol. 2014; 5: 21. | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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