Target expression details
| Target's General Information | |||||
|---|---|---|---|---|---|
| Target ID | T14558 | ||||
| Target Name | Tryptase alpha/beta-1 (Tryptase) | ||||
| Synonyms | Tryptase-1; Tryptase alpha-1; Tryptase I; TPSB1; TPS2; TPS1 | ||||
| Target Type | Successful | ||||
| Gene Name | TPSAB1 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | TRYB1_HUMAN | ||||
| Target's Expression Profile in Disease Related Tissue between Patients and Normal People | |||||
| Disease | Asthma | ||||
| Example drug | APC-366 | Discontinued in Phase 2 | [1], [2], [3] | ||
| Tissue | Nasal and bronchial airway | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual |
Fold-change: 1.07 Z-score: 0.89 P-value: 3.09E-07 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target's Expression Profile across Various Tissues of Healthy Individual | |||||
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| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003595) | ||||
| REF 2 | Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41. | ||||
| REF 3 | NCBI GEO: archive for functional genomics data sets--update. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5. | ||||
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