Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
DZLM72
|
|||
Drug Name |
SHR0534
|
|||
Indication | Type 2 diabetes [ICD-11: 5A11; ICD-10: E08-E13] | Phase 1 | [1] | |
Company |
Jiangsu Hengrui
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Free fatty acid receptor 1 (GPR40) | Target Info | Agonist | [2] |
Inflammation-related GPCR EX33 (GPR84) | Target Info | Agonist | [2] | |
KEGG Pathway | Insulin secretion | |||
Reactome | G alpha (q) signalling events | |||
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion | ||||
WikiPathways | GPCRs, Class A Rhodopsin-like | |||
Incretin Synthesis, Secretion, and Inactivation | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Integration of energy metabolism | ||||
GPCR ligand binding | ||||
GPCR downstream signaling |
References | Top | |||
---|---|---|---|---|
REF 1 | ClinicalTrials.gov (NCT03006159) A Phase 1, Randomized, Placebo-controlled, Multiple Dose Escalation Study to Investigate Safety, Pharmacokinetics, and Pharmacodynamics of SHR0534 in Chinese Type 2 Diabetic Patients. U.S. National Institutes of Health. | |||
REF 2 | Targeting metabolic dysregulation for fibrosis therapy. Nat Rev Drug Discov. 2020 Jan;19(1):57-75. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.