Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DZ8UP4
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| Drug Name |
LM10
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| Synonyms |
1316695-35-8; (E)-3-(2-(1H-TETRAZOL-5-YL)VINYL)-6-FLUORO-1H-INDOLE; CHEMBL1812545; LM-10; 6-fluoro-3-[(E)-2-(1H-1,2,3,4-tetrazol-5-yl)ethenyl]-1H-indole; 6-Fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole; 1H-Indole, 6-fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-; LM 10; GTPL9016; SCHEMBL16820602; SCHEMBL16820603; BDBM311862; CS-D0342; BDBM50350248; MFCD26097257; s8368; US10155972, Compound LM10; ZINC72108665; AKOS024464444; CCG-266788; AS-30527; Q27081058
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Preclinical | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C11H8FN5
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| Canonical SMILES |
C1=CC2=C(C=C1F)NC=C2C=CC3=NNN=N3
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| InChI |
1S/C11H8FN5/c12-8-2-3-9-7(6-13-10(9)5-8)1-4-11-14-16-17-15-11/h1-6,13H,(H,14,15,16,17)/b4-1+
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| InChIKey |
JDBSZVDIUIRSDG-DAFODLJHSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Tryptophan 2,3-dioxygenase (TDO) | Target Info | Inhibitor | [2] |
| KEGG Pathway | Tryptophan metabolism | |||
| Metabolic pathways | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. | |||
| REF 2 | The autoimmune response elicited by mouse hepatitis virus (MHV-A59) infection is modulated by liver tryptophan-2,3-dioxygenase (TDO). Immunol Lett. 2020 Jan;217:25-30. | |||
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