Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DY9CM8
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| Drug Name |
BRD1240
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| Synonyms |
BRD-1240; 3-(1,3-benzodioxol-5-yl)-1-[[(4S,5S)-2-[(2S)-1-hydroxypropan-2-yl]-4-methyl-1,1-dioxo-8-(2-pyridin-4-ylethynyl)-4,5-dihydro-3H-6,1$l^{6},2-benzoxathiazocin-5-yl]methyl]-1-methylurea; CHEMBL2355724; CHEBI:96315; BRD-K63431240-001-01-4; BRD-K63431240-001-02-2; Q27168409
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| Drug Type |
Small molecular drug
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Investigative | [1] | |
| Company |
Harvard University
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| Structure |
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Download2D MOL |
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| Formula |
C30H32N4O7S
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| Canonical SMILES |
CC1CN(S(=O)(=O)C2=C(C=C(C=C2)C#CC3=CC=NC=C3)OC1CN(C)C(=O)NC4=CC5=C(C=C4)OCO5)C(C)CO
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| InChI |
1S/C30H32N4O7S/c1-20-16-34(21(2)18-35)42(37,38)29-9-6-23(5-4-22-10-12-31-13-11-22)14-27(29)41-28(20)17-33(3)30(36)32-24-7-8-25-26(15-24)40-19-39-25/h6-15,20-21,28,35H,16-19H2,1-3H3,(H,32,36)/t20-,21-,28+/m0/s1
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| InChIKey |
OYKBHWDUAQJSNT-YHGPEZAFSA-N
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| PubChem Compound ID | ||||
| ChEBI ID |
CHEBI:96315
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Vacuolar-type proton ATPase (v-ATPase) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Discovery of a Small-Molecule Probe for V-ATPase Function. J Am Chem Soc. 2015 Apr 29;137(16):5563-8. | |||
| REF 2 | Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948. | |||
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