Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DY0HV9
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| Drug Name |
GSK366
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| Synonyms |
CHEMBL4081917; GSK 366; 1953157-39-5; (R)-3-(5-Chloro-6-(1-(6-methylpyridazin-3-yl)ethoxy)benzo[d]isoxazol-3-yl)propanoic acid; 3-[5-Chloranyl-6-[(1~{r})-1-(6-Methylpyridazin-3-Yl)ethoxy]-1,2-Benzoxazol-3-Yl]propanoic Acid; SCHEMBL17844503; EX-A4734; BDBM50266002; HY-119171; CS-0069358; ClC=1C(=CC2=C(C(=NO2)CCC(=O)O)C=1)O[C@H](C)C=1N=NC(=CC=1)C; 8RB
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| Drug Type |
Small molecular drug
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| Indication | Pancreatitis [ICD-11: DC31-DC34] | Preclinical | [1] | |
| Company |
GlaxoSmithKline
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| Structure |
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Download2D MOL |
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| Formula |
C17H16ClN3O4
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| Canonical SMILES |
CC1=NN=C(C=C1)C(C)OC2=C(C=C3C(=C2)ON=C3CCC(=O)O)Cl
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| InChI |
1S/C17H16ClN3O4/c1-9-3-4-13(20-19-9)10(2)24-16-8-15-11(7-12(16)18)14(21-25-15)5-6-17(22)23/h3-4,7-8,10H,5-6H2,1-2H3,(H,22,23)/t10-/m1/s1
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| InChIKey |
YWASLAPMFGBZQP-SNVBAGLBSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Kynurenine 3-hydroxylase (KMO) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. | |||
| REF 2 | Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827. | |||
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