Drug Information
Drug General Information | Top | |||
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Drug ID |
DTP85B
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Drug Name |
Hippuristanol
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Synonyms |
80442-78-0; SCHEMBL1374807; CHEMBL1098427; DTXSID50433627; BDBM50235738; Q10861089
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Drug Type |
Small molecular drug
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Indication | T-cell leukaemia [ICD-11: 2A90; ICD-10: C86] | Investigative | [1] | |
Structure |
Download2D MOL |
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Formula |
C28H46O5
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Canonical SMILES |
CC1CC2(C(C3C(O2)CC4C3(CC(C5C4CCC6C5(CCC(C6)O)C)O)C)(C)O)OC1(C)C
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InChI |
1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1
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InChIKey |
HPHXKNOXVBFETI-SHCCRYCOSA-N
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CAS Number |
CAS 80442-78-0
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | HUMAN eukaryotic initiation factor-4A (eIF4A) | Target Info | Inhibitor | [2] |
References | Top | |||
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REF 1 | Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A. Translation (Austin). 2016 Jan 4;4(1):e1137381. | |||
REF 2 | Effects of hippuristanol, an inhibitor of eIF4A, on adult T-cell leukemia. Biochem Pharmacol. 2011 Mar 15;81(6):713-22. |
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