Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DN28KM
|
|||
| Drug Name |
GEN1042
|
|||
| Drug Type |
Antibody
|
|||
| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Phase 1 | [1] | |
| Company |
GenMab
|
|||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | CD40L receptor (CD40) | Target Info | Agonist | [2] |
| Co-stimulatory molecule 4-1BB (CD137) | Target Info | Agonist | [2] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| NF-kappa B signaling pathway | ||||
| Cell adhesion molecules (CAMs) | ||||
| Toll-like receptor signaling pathway | ||||
| Intestinal immune network for IgA production | ||||
| Malaria | ||||
| Toxoplasmosis | ||||
| HTLV-I infection | ||||
| Epstein-Barr virus infection | ||||
| Transcriptional misregulation in cancer | ||||
| Asthma | ||||
| Autoimmune thyroid disease | ||||
| Systemic lupus erythematosus | ||||
| Allograft rejection | ||||
| Primary immunodeficiency | ||||
| Viral myocarditis | ||||
| NetPath Pathway | TCR Signaling Pathway | |||
| Pathway Interaction Database | CD40/CD40L signaling | |||
| Downstream signaling in naï | ||||
| WikiPathways | Toll-like receptor signaling pathway | |||
| Inflammatory Response Pathway | ||||
| NLR Proteins | ||||
| Vitamin D Receptor Pathway | ||||
| Human Complement System | ||||
| Allograft Rejection | ||||
| Regulation of toll-like receptor signaling pathway | ||||
| TCR Signaling Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT04083599) GEN1042 Safety Trial in Subjects With Malignant Solid Tumors. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of Genmab. | |||
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