Drug Information
Drug General Information | Top | |||
---|---|---|---|---|
Drug ID |
DJX61M
|
|||
Drug Name |
Vudalimab
|
|||
Drug Type |
Bispecific antibody
|
|||
Indication | Prostate cancer [ICD-11: 2C82.0; ICD-9: 185] | Phase 2 | [1] | |
Company |
Xencor
|
Target and Pathway | Top | |||
---|---|---|---|---|
Target(s) | Cytotoxic T-lymphocyte protein 4 (CTLA-4) | Target Info | . | [2] |
Programmed cell death protein 1 (PD-1) | Target Info | . | [2] | |
KEGG Pathway | Cell adhesion molecules (CAMs) | |||
T cell receptor signaling pathway | ||||
Autoimmune thyroid disease | ||||
Rheumatoid arthritis | ||||
Pathway Interaction Database | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | |||
Reactome | CTLA4 inhibitory signaling | |||
PD-1 signaling | ||||
WikiPathways | Vitamin D Receptor Pathway | |||
T-Cell Receptor and Co-stimulatory Signaling | ||||
Allograft Rejection | ||||
Costimulation by the CD28 family |
References | Top | |||
---|---|---|---|---|
REF 1 | ClinicalTrials.gov (NCT05005728) Phase 2 Multiple-Dose, Multiple-Arm, Parallel Assignment Study to Evaluate the Safety, Tolerability, and Preliminary Efficacy of XmAb?20717 Alone or in Combination With Chemotherapy or Targeted Therapies in Selected Subjects With Metastatic Castration-Resistant Prostate Cancer. U.S.National Institutes of Health. | |||
REF 2 | Clinical pipeline report, company report or official report of Xencor |
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