Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DGV8K5
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| Drug Name |
GSK065
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| Synonyms |
CHEMBL4091152; (R)-3-(5-Chloro-6-(1-(pyridin-2-yl)ethoxy)benzo[d]isoxazol-3-yl)propanoic acid; 3-[5-Chloranyl-6-[(1~{r})-1-Pyridin-2-Ylethoxy]-1,2-Benzoxazol-3-Yl]propanoic Acid; 1953156-61-0; 8R5; SCHEMBL17844622; GTPL10358; BDBM50266003; GSK3335065; inhibitor C1 [PMID: 28604669]; ClC=1C(=CC2=C(C(=NO2)CCC(=O)O)C=1)O[C@H](C)C1=NC=CC=C1
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| Drug Type |
Small molecular drug
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| Indication | Pancreatitis [ICD-11: DC31-DC34] | Phase 1 | [1] | |
| Company |
GlaxoSmithKline
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| Structure |
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Download2D MOL |
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| Formula |
C17H15ClN2O4
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| Canonical SMILES |
CC(C1=CC=CC=N1)OC2=C(C=C3C(=C2)ON=C3CCC(=O)O)Cl
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| InChI |
1S/C17H15ClN2O4/c1-10(13-4-2-3-7-19-13)23-16-9-15-11(8-12(16)18)14(20-24-15)5-6-17(21)22/h2-4,7-10H,5-6H2,1H3,(H,21,22)/t10-/m1/s1
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| InChIKey |
WPAHVUADNLXSOM-SNVBAGLBSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Kynurenine 3-hydroxylase (KMO) | Target Info | Inhibitor | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. | |||
| REF 2 | Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827. | |||
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