Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DFBJ28
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| Drug Name |
6-Formylindolo[3,2-b]carbazole
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| Synonyms |
Indolo[3,2-b]carbazole-6-carbaldehyde; 1555757-10-2; indolo[3,2-b]carbazole-12-carbaldehyde; SCHEMBL528518; ANW-57186; MFCD23140892; ZINC39957465; AKOS015837457; AKOS025396684; FT-0678209
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| Drug Type |
Small molecular drug
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| Indication | Dermatitis [ICD-11: EA80-EA89; ICD-9: 692.9] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C19H10N2O
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| Canonical SMILES |
C1=CC=C2C(=C1)C3=CC4=NC5=CC=CC=C5C4=C(C3=N2)C=O
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| InChI |
1S/C19H10N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10H
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| InChIKey |
OTWFDHQTFRXSAK-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Aryl hydrocarbon receptor (AHR) | Target Info | Agonist | [2] |
| References | Top | |||
|---|---|---|---|---|
| REF 1 | Protective role of 6-formylindolo[3,2-b]carbazole (FICZ), an endogenous ligand for arylhydrocarbon receptor, in chronic mite-induced dermatitis. J Dermatol Sci. 2018 Jun;90(3):284-294. | |||
| REF 2 | 6-Formylindolo(3,2-b)carbazole induced aryl hydrocarbon receptor activation prevents intestinal barrier dysfunction through regulation of claudin-2 expression. Chem Biol Interact. 2018 May 25;288:83-90. | |||
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