Drug Information
Drug General Information | Top | |||
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Drug ID |
DF1S3A
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Drug Name |
GSK180
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Synonyms |
1799725-26-0; CHEMBL4092205; 3-(5,6-dichloro-2-oxo-1,3-benzoxazol-3-yl)propanoic acid; 3-(5,6-Dichloro-2-Oxobenzo[d]oxazol-3(2h)-Yl)propanoic Acid; JHY; GTPL9007; SCHEMBL16836556; GSK-180; BCP33987; EX-A4035; GSK 180; GSK-180; BDBM50266036; SB19707; inhibitor A1 [PMID: 28604669]; HY-112179; CS-0043620; ClC=1C(=CC2=C(N(C(O2)=O)CCC(=O)O)C1)Cl; Q27077878
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Drug Type |
Small molecular drug
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Indication | Neurodegenerative disorder [ICD-11: 8A20-8A23] | Preclinical | [1] | |
Pancreatitis [ICD-11: DC31-DC34] | Preclinical | [1] | ||
Company |
GlaxoSmithKline
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Structure |
Download2D MOL |
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Formula |
C10H7Cl2NO4
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Canonical SMILES |
C1=C2C(=CC(=C1Cl)Cl)OC(=O)N2CCC(=O)O
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InChI |
1S/C10H7Cl2NO4/c11-5-3-7-8(4-6(5)12)17-10(16)13(7)2-1-9(14)15/h3-4H,1-2H2,(H,14,15)
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InChIKey |
MIGAKMWKMLYGJX-UHFFFAOYSA-N
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PubChem Compound ID |
Target and Pathway | Top | |||
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Target(s) | Kynurenine 3-hydroxylase (KMO) | Target Info | Inhibitor | [1] |
References | Top | |||
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REF 1 | Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401. |
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