Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DCVO04
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| Drug Name |
OSU-53
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| Synonyms |
CHEMBL597622; 1290069-19-0; n-{4-[3-(1-methyl-cyclohexylmethyl)-2,4-dioxo-thiazolidin-5-ylidenemethyl]-phenyl}-4-nitro-3-trifluoromethyl-benzenesulfonamide; SCHEMBL1615001; BDBM50503138
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| Drug Type |
Small molecular drug
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| Indication | Triple negative breast cancer [ICD-11: 2C60-2C65] | Investigative | [1] | |
| Structure |
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Download2D MOL |
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| Formula |
C25H24F3N3O6S2
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| Canonical SMILES |
CC1(CCCCC1)CN2C(=O)C(=CC3=CC=C(C=C3)NS(=O)(=O)C4=CC(=C(C=C4)[N+](=O)[O-])C(F)(F)F)SC2=O
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| InChI |
1S/C25H24F3N3O6S2/c1-24(11-3-2-4-12-24)15-30-22(32)21(38-23(30)33)13-16-5-7-17(8-6-16)29-39(36,37)18-9-10-20(31(34)35)19(14-18)25(26,27)28/h5-10,13-14,29H,2-4,11-12,15H2,1H3/b21-13-
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| InChIKey |
FANMQRSNMHKZCR-BKUYFWCQSA-N
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| PubChem Compound ID | ||||
| References | Top | |||
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| REF 1 | Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator. J Biol Chem. 2011 Nov 11;286(45):39247-58. | |||
| REF 2 | A novel dual AMPK activator/mTOR inhibitor inhibits thyroid cancer cell growth. J Clin Endocrinol Metab. 2015 May;100(5):E748-56. | |||
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