Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
DC5A9Q
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| Drug Name |
mRNA-2752
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| Synonyms |
mRNA-OX40L/IL-23/IL-36 gamma
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|
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| Drug Type |
mRNA therapy
|
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| Indication | Solid tumour/cancer [ICD-11: 2A00-2F9Z; ICD-10: C00-D48; ICD-9: 140-199] | Phase 1 | [1] | |
| Company |
Moderna Therapeutics
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| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Interleukin-23 (IL23) | Target Info | Replacement | [2] |
| Interleukin-36 gamma (IL36G) | Target Info | Replacement | [2] | |
| TAX transcriptionally-activated glycoprotein 1 (OX40) | Target Info | Replacement | [2] | |
| KEGG Pathway | Cytokine-cytokine receptor interaction | |||
| Toll-like receptor signaling pathway | ||||
| RIG-I-like receptor signaling pathway | ||||
| Jak-STAT signaling pathway | ||||
| Type I diabetes mellitus | ||||
| Pertussis | ||||
| Legionellosis | ||||
| Leishmaniasis | ||||
| Chagas disease (American trypanosomiasis) | ||||
| African trypanosomiasis | ||||
| Malaria | ||||
| Toxoplasmosis | ||||
| Amoebiasis | ||||
| Tuberculosis | ||||
| Measles | ||||
| Influenza A | ||||
| Herpes simplex infection | ||||
| Inflammatory bowel disease (IBD) | ||||
| Allograft rejection | ||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | |||
| TSLP Signaling Pathway | ||||
| Reactome | TNFs bind their physiological receptors | |||
| WikiPathways | Toll-like receptor signaling pathway | |||
| Aryl Hydrocarbon Receptor Pathway | ||||
| Allograft Rejection | ||||
| Regulation of toll-like receptor signaling pathway | ||||
| Vitamin D Receptor Pathway | ||||
| TSLP Signaling Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT03739931) Dose Escalation Study of mRNA-2752 for Intratumoral Injection to Participants With Advanced Malignancies. U.S. National Institutes of Health. | |||
| REF 2 | Clinical pipeline report, company report or official report of Moderna Therapeutics. | |||
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