Drug Information
| Drug General Information | Top | |||
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| Drug ID |
DA29IM
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| Drug Name |
Dotinurad
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| Synonyms |
Dotinurad; 1285572-51-1; FYU-981; Dotinurad [INN]; (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone; 305EB53128; (3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2H-1,3-benzothiazol-3-yl)methanone; Urece; Methanone, (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxido-3(2H)-benzothiazolyl)-; Urece (TN); Dotinurad (JAN/INN); DOTINURAD [JAN]; DOTINURAD [WHO-DD]; FYU981; CHEMBL4594446; SCHEMBL10322525; GTPL11389; VOFLAIHEELWYGO-UHFFFAOYSA-N; UNII-305EB53128; EX-A5737; BDBM50561689; AKOS040741664; HY-109031; CS-0030545; D11071; 3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole
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| Drug Type |
Small molecule
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| Indication | Gout [ICD-11: FA25; ICD-10: M10] | Phase 3 | [1] | |
| Company |
UR-1 Therapeutics Miami, FL
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| Structure |
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Download2D MOL |
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| Formula |
C14H9Cl2NO4S
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| Canonical SMILES |
C1N(C2=CC=CC=C2S1(=O)=O)C(=O)C3=CC(=C(C(=C3)Cl)O)Cl
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| InChI |
InChI=1S/C14H9Cl2NO4S/c15-9-5-8(6-10(16)13(9)18)14(19)17-7-22(20,21)12-4-2-1-3-11(12)17/h1-6,18H,7H2
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| InChIKey |
VOFLAIHEELWYGO-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Urate anion exchanger 1 (URAT1) | Target Info | Inhibitor | [2] |
| WikiPathways | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | |||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | ClinicalTrials.gov (NCT05007392) A Randomized, Multicenter, Double-Blind, Superiority Study of Dotinurad (4 mg) and Febuxostat (40 mg) for the Treatment of Subjects With Gout. U.S.National Institutes of Health. | |||
| REF 2 | Dotinurad: a novel selective urate reabsorption inhibitor for the treatment of hyperuricemia and gout. Expert Opin Pharmacother. 2021 Aug;22(11):1397-1406. | |||
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